2016 Publications

Utility of overnight pulse oximeter as a screening tool for sleep apnea to assess the 8-year risk of cardiovascular disease: Data from a large-scale bus driver cohort study
Wu, WT;Tsai, SS;Lin, YJ;Lin, MH;Wu, TN;Shih, TS;Liou, SH
Abstract: Background Professional drivers’ work under conditions predisposes them for development of sleep-disordered breathing (SDB) and cardiovascular disease (CVD). However, the effect of SDB on CVD risk among professional drivers has never been investigated. A cohort study was used to evaluate the effectiveness of overnight pulse oximeter as a sleep apnea screening tool to assess the 8-year risk of CVD events.(more)

Association study between melanocortin-1 receptor gene polymorphisms and occurrence of vitiligo in a Taiwanese population: Possible explanation for lack of increased UV-related damage in vitiligo skin
Yu, S;Yu, HS;Tu, HP;Wu, CS;Lan, CC

Impact of work-related cancers in Taiwan-Estimation with QALY (quality-adjusted life year) and healthcare costs
Lee, LJH;Lin, CK;Hung, MC;Wang, JD
Abstract: This study estimates the annual numbers of eight work-related cancers, total losses of quality-adjusted life years (QALYs), and lifetime healthcare expenditures that possibly could be saved by improving occupational health in Taiwan. Three databases were interlinked: the Taiwan Cancer Registry, the National Mortality Registry, and the National Health Insurance Research Database.(more)

Pharmacokinetics and bioavailability of oral single-dose maleic acid in biofluids of Sprague-Dawley rats
Wu, C;Chen, HC;Luo, YS;Chiang, SY;Wu, KY
Abstract: Maleic acid (MA) was purposefully adulterated in an array of starch-based foods in Taiwan, inciting a food safety incident. Due to limited data on the pharmacokinetics and bioavailability of ingested MA, we studied pharmacokinetic (PK) parameters in serum and urine of Sprague Dawley rats.(more)

Health-related quality of life in patients with Barrett’s esophagus
Chang, CY;Lee, LJ;Wang, JD;Lee, CT;Tai, CM;Tang, TQ;Lin, JT
Abstract:BACKGROUND: Gastroesophageal reflux disease (GERD) has become a major health problem globally, affecting patients’ health-related quality of life (HRQOL).(more)

Prenatal exposure to perfluorocarboxylic zcids (PFCAs) and fetal and postnatal growth in the Taiwan maternal and infant cohort study
Wang, Y;Adgent, M;Su, PH;Chen, HY;Chen, PC;Hsiung, CA;Wang, SL
Abstract: BACKGROUND: Perfluorocarboxylic acids (PFCAs) are environmentally and biologically persistent synthetic chemicals. PFCAs include perfluorooctanoic acid (PFOA, C8) and long-chain PFCAs (C9-C20). Studies examining long-chain PFCAs and fetal and postnatal growth are limited. OBJECTIVES: To investigate the associations of prenatal exposure to long chain PFCAs and fetal and postnatal growth. (more)

Increased levels of oxidative stress biomarkers in metal oxides nanomaterial-handling workers
Liou, SH;Chen, YC;Liao, HY;Wang, CJ;Chen, JS;Lee, HL
Abstract:This study assessed oxidatively damaged DNA and antioxidant enzyme activity in workers occupational exposure to metal oxides nanomaterials. Exposure to TiO2, SiO2, and ITO resulted in significant lower antioxidant enzymes (glutathione peroxidase and superoxide dismutase) and higher oxidative biomarkers 8-hydroxydeoxyguanosine (8-oxodG) than comparison workers. (more)

Ambient PM2.5-bound polycyclic aromatic hydrocarbons (PAHs) in Changhua County, central Taiwan: Seasonal variation, source apportionment and cancer risk assessment
Chen, YC;Chiang, HC;Hsu, CY;Yang, TT;Lin, TY;Chen, MJ;Chen, NT;Wu, YS
Abstract: This study investigates PM2.5-bound PAHs for rural sites (Dacheng and Fangyuan) positioned close to heavy air-polluting industries in Changhua County, central Taiwan. A total of 113 PM2.5 samples with 22 PAHs collected from 2014 to 2015 were analyzed, and Positive Matrix Factorization (PMF) and diagnostic ratios of PAHs were applied to quantify potential PAH sources. (more)

Field performance of a semi-continuous monitor for ambient PM2.5 water-soluble inorganic ions and gases at a suburban site
Young, LH;Li, CH;Lin, MY;Hwang, BF;Hsu, HT;Chen, YC;Jung, CR;Chen, KC;Cheng, DH;Wang, VS;Chiang, HC;Tsai, PJ
Abstract: To reduce sampling artifacts and to improve time-resolved measurements of inorganic aerosol system, a recently commercialized semi-continuous In-situ Gas and Aerosol Composition (IGAC) monitoring system was evaluated against a reference annular denuder system (more)

Levels and toxicological effects of heavy and trace metals in cigarette sidestream smoke particulates
Li, LA;Cheng, LC;Chung, WC;Liu, HJ
Abstract: Introduction: Heavy and trace metals present in tobacco are discharged as part of tobacco smoke during smoking. It has long been known that excessive exposure to heavy and trace metals is harmful to health.(more)

SHP-2 phosphatase controls aryl hydrocarbon receptor-mediated ER stress response in mast cells
Wang, HC;Zhou, Y;Huang, SK
Abstract: Previously we reported that exposure of mouse and human mast cells to aryl hydrocarbon receptor (AhR) ligands resulted in reactive oxygen species (ROS)- and calcium (Ca2+)-dependent activation of mast cells in vitro and in vivo.(more)

Assessment of urinary thiodiglycolic acid exposure in school-aged children in the vicinity of a petrochemical complex in central Taiwan
Huang, PC;Liu, LH;Shie, RH;Tsai, CH;Liang, WY;Wang, CW;Tsai, CH;Chiang, HC;Chan, CC
Abstract: BACKGROUND: School-aged children living in the vicinity of vinyl chloride (VCM)/polyvinyl chloride (PVC) factories may have an increased risk of exposure to hazardous air pollutants. OBJECTIVES: We aimed to evaluate the urinary thiodiglycolic acid (TDGA) level, as TDGA is a major metabolite of VCM, for students at elementary schools near a petrochemical complex in central Taiwan.(more)

Schoolchildren’s antioxidation genotypes are susceptible factors for reduced lung function and airway inflammation caused by air pollution
Chen, BY;Chen, CH;Chuang, YC;Kim, H;Honda, Y;Chiang, HC;Guo, YL
Abstract: BACKGROUND: We recently reported the relationship between exposure to ambient air pollutants and changes in lung function and nasal inflammation among schoolchildren. A study was conducted to investigate whether antioxidation genotypes influence these associations. METHODS: A follow-up study of 97 schoolchildren was conducted in New Taipei City, Taiwan. (more)

A new grid-scale model simulating the spatiotemporal distribution of PM2.5-PAHs for exposure assessment
Lee, CL;Huang, HC;Wang, CC;Sheu, CC;Wu, CC;Leung, SY;Lai, RS;Lin, CC;Wei, YF;Lai, IC;Jiang, H;Chou, WL;Chung, WY;Huang, MS;Huang, SK
Abstract: Exposure to polycyclic aromatic hydrocarbons (PAHs) associated with ambient air particulate matter (PM) poses significant health concerns. Several modeling approaches have been developed for simulating ambient PAHs, but no hourly intra-urban spatial data are currently available. The aim of this study is to develop a new modeling strategy in simulating, on an hourly basis, grid-scale PM2.5-PAH levels.(more)

Benzopyrene, a major polyaromatic hydrocarbon in smoke fume, mobilizes Langerhans cells and polarizes Th2/17 responses in epicutaneous protein sensitization through the aryl hydrocarbon receptor
Hong, CH;Lee, CH;Yu, HS;Huang, SK
Abstract: BACKGROUND: Atopic dermatitis (AD) is a common disease with genetic and environmental interactions. We previously reported lifetime exposure to cigarette smoke is associated with adult-onset AD. Aryl hydrocarbon receptor (AhR) is important in regulating environmental exposure to xenobiotics, including benzopyrenes (BP), a major polycyclic aromatic hydrocarbon (PAH) present in cigarette smoke. (more)

Role of mitochondria, ROS, and DNA damage in arsenic induced carcinogenesis
Lee, CH;Yu, HS
Abstract: The International Agency for Research on Cancer (IARC) declared arsenic a class I carcinogen. Arsenic exposure induces several forms of human cancers, including cancers of skin, lung, liver, and urinary bladder. The majority of the arsenic-induced cancers occur in skin.(more)

Estrogenic effects in the influents and effluents of the drinking water treatment plants
Gou, YY;Lin, S;Que, DE;Tayo, LL;Lin, DY;Chen, KC;Chen, FA;Chiang, PC;Wang, GS;Hsu, YC;Chuang, KP;Chuang, CY;Tsou, TC;Chao, HR
Abstract: Estrogen-like endocrine disrupting compounds (EEDC) such as bisphenol A, nonylphenol, and phthalic acid esters are toxic compounds that may occur in both raw- and drinking water. The aim of this study was to combine chemical- and bioassay to evaluate the risk of EEDCs in the drinking water treatment plants (DWTPs).(more)

Ultraviolet B (UVB) induces development of early melanocytic progenitors via increased oxidative stress in vitro – Implications for use of oral antioxidants in UVB phototherapy for vitiligo treatment
Yu, S;Yu, H;Wu, C;Lan, C
Abstract: Antioxidants are often used as an adjuvant therapy with ultraviolet B (UVB) phototherapy, whereas the mechanistic cascade involved in this combination therapy remains to be clarified. Using NCCMelb4M5 cells, which represent early melanocytic progenitors, we demonstrated oxidative stress plays a functional role in early differentiation of melanocytic progenitors.(more)

Cyclin D1 promoter -56 and -54 bp CpG un-methylation predicts invasive progression in arsenic-induced Bowen’s disease
Yu, H;Liao, W;Chai, C;Lee, C
Abstract: The epidermis forms a critical physical and immune barrier. Dysregulation of keratinocyte to cell death upon external stimuli could compromise the epidermal barrier immunity and cause skin inflammation. Gasdermin A was involved in gastric epithelial apoptosis; its function in the skin was hinted by the skin inflammation and hair loss phenotype in mice with dominant mutations in gasdermin A3 (Gsdma3).(more)

Nuclear accumulation of heat-shock protein 90 is associated with poor survival and metastasis in patients with non-small cell lung cancer
Su, JM;Hsu, YY;Lin, P;Chang, H
Abstract: BACKGROUND/AIM: Heat-shock protein 90 (HSP90) is a molecular chaperone that stabilizes many client proteins in normal and cancer cells, and approximately 3% of intracellular HSP90 is located in the nucleus. HSP90 is also targeted for the treatment of advanced non-small cell lung cancer (NSCLC). This study aimed to elucidate the clinical role of nuclear HSP90 levels in tissues from patients with NSCLC.(more)

Sirtuin 3 protects against urban particulate matter-induced autophagy in human bronchial epithelial cells
Chen, IC;Huang, HH;Chen, PF;Chiang, HC
Abstract: Urban particulate matter (urban PM) is a heterogeneous mixture of various types of particles originating from different sources. Exposure to high concentrations of urban PM leading to adverse health effects is evaluated by using in vitro cultures of human lung epithelial cells.(more)

Age of asthma onset and vulnerability to ambient air pollution: An observational population-based study of adults from Southern Taiwan
Wu, TJ;Wu, CF;Chen, BY;Lee, YL;Guo, YL
Abstract: BACKGROUND: Late-onset asthma (onset > 12 years) is pathologically distinct from early-onset asthma. The mechanism of air pollution is not a classic allergic inflammation and could have differential effect on late-onset and early-onset asthma. However, there is little known about the association of onset-age phenotype and air pollution. In this population-based study, we aimed to determine the association of asthma severity outcomes and air pollution regarding age at onset of asthma.(more)

Intake of phthalate-tainted foods and microalbuminuria in children: The 2011 Taiwan food scandal
Tsai, HJ;Chen, BH;Wu, CF;Wang, SL;Huang, PC;Tsai, YC;Chen, ML;Ho, CK;Hsiung, CA;Wu, MT
Abstract: Background: A major threat to public health involving phthalate-tainted foodstuffs occurred in Taiwan in 2011. Phthalates, mainly di-(2-ethylhexyl) phthalate (DEHP), were intentionally added to several categories of food commonly consumed by children. This study investigated the relationship between intake of the phthalate-tainted foods and renal function in children.(more)

Increased levels of oxidative stress biomarkers in metal oxides nanomaterial-handling workers
Liou, SH;Chen, YC;Liao, HY;Wang, CJ;Chen, JS;Lee, HL
Abstract: This study assessed oxidatively damaged DNA and antioxidant enzyme activity in workers occupational exposure to metal oxides nanomaterials. Exposure to TiO2, SiO2, and ITO resulted in significant lower antioxidant enzymes (glutathione peroxidase and superoxide dismutase) and higher oxidative biomarkers 8-hydroxydeoxyguanosine (8-oxodG) than comparison workers.(more)

Arsenite regulates prolongation of glycan residues of membrane glycoprotein: A pivotal study via wax physisorption kinetics and FTIR imaging
Lee, CH;Hsu, CY;Huang, PY;Chen, CI;Lee, YC;Yu, HS
Abstract: Arsenic exposure results in several human cancers, including those of the skin, lung, and bladder. As skin cancers are the most common form, epidermal keratinocytes (KC) are the main target of arsenic exposure. The mechanisms by which arsenic induces carcinogenesis remains unclear, but aberrant cell proliferation and dysregulated energy homeostasis play a significant role.(more)

The effects of coarse particles on daily mortality: A case-crossover study in a subtropical city, Taipei, Taiwan
Cheng, MH;Chiu, HF;Yang, CY
Abstract: Many studies have examined the effects of air pollution on daily mortality over the past two decades. However, information on the relationship between levels of coarse particles (PM2.5-10) and daily mortality is relatively sparse due to the limited availability of monitoring data. Furthermore, the results are inconsistent.(more)

Exposure estimation for risk assessment of the phthalate incident in Taiwan
Chen, CC;Wang, SL;Wu, MT;Wang, YH;Huang, PC;Chen, BH;Sun, CW;Ho, CK;Shih, YC;Shiu, MN;Pan, WH;Chen, ML;Lee, CC;Hsiung, CA
Abstract: BACKGROUND: In May 2011, di(2-ethylhexyl) phthalates (DEHP) and, to a lesser extent, di-iso-nonyl phthalate (DiNP) were found to have been illegally used for many years in Taiwan as clouding agents in foods including sports drinks, juice beverages, tea drinks, fruit jam/nectar/jelly, and health or nutrient supplements. (more)

Mono(2-ethylhexyl)phthalate accumulation disturbs energy metabolism of fat cells
Chiang, HC;Kuo, YT;Shen, CC;Lin, YH;Wang, SL;Tsou, TC
Abstract: Phthalates are lipophilic and tend to accumulate in adipose tissue, an important regulator of energy balance and glucose homeostasis. The study aimed to determine whether cellular phthalate accumulation influenced fat cell energy metabolism. Following a 3-day treatment with adipogenesis-inducing medium and a 2-day treatment with adipogenesis-maintaining medium, 3T3-L1 cells differentiated into adipocytes in the presence of a phthalate at a clinically relevant concentration (30-300 muM) for another 6 days. (more)

Fine particle pollution, alanine transaminase, and liver cancer: A Taiwanese prospective cohort study (REVEAL-HBV)
Pan, WC;Wu, CD;Chen, MJ;Huang, YT;Chen, CJ;Su, HJ;Yang, HI
Abstract: BACKGROUND: Exposure to fine particulate matter (PM2.5) may promote hepatic tumorgenesis through low-grade inflammation. Therefore, we assessed the association of long-term exposure levels of PM2.5 and subsequent risk of hepatocellular carcinoma (HCC) and investigated the mediation effect of inflammation as represented by alanine aminotransferase (ALT) on this association. (more)

An improved estrogenic activity reporter gene assay (T47D-KBluc) for detecting estrogenic activity in wastewater and drinking water
Chou, HM;Chao, HR;Lin, C;Chiang, PC;Wang, GS;Tsou, TC
Abstract: The estrogenic activity reporter gene assay (T47D-KBluc assay) is a useful method for detecting estrogenic activity in wastewater, but its resolving power and sensitivity are unsuitable in tap or drinking water. (more)

Differential immunological effects of infrared irradiation and its associated heat in vivo
Lee, CH;Hong, CH;Liao, WT;Yu, HS
Abstract: Infrared irradiation (IR) is the most abundant fraction of sunlight reaching the earth’s surface and provides heat. The fever response of an animal is known to regulate its immune responses. However, the non-thermal immune responses of IR were difficult to assess owing to its close association with heat. (more)

Assessing coughing-induced influenza droplet transmission and implications for infection risk control
Cheng, YH;Wang, CH;You, SH;Hsieh, NH;Chen, WY;Chio, CP;Liao, CM
Abstract: Indoor transmission of respiratory droplets bearing influenza within humans poses high risks to respiratory function deterioration and death. Therefore, we aimed to develop a framework for quantifying the influenza infection risk based on the relationships between inhaled/exhaled respiratory droplets and airborne transmission dynamics in a ventilated airspace. (more)

Reducing polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) emissions from a real-scale iron ore sinter plant by adjusting its sinter raw mix
Chen, YC;Kuo, YC;Chen, MR;Wang, YF;Chen, CH;Lin, MY;Yoon, C;Tsai, PJ
Abstract: This study was conducted in a real-scale iron ore sinter plant for reducing emissions of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) from the iron ore sintering process via the adjustment of its sinter raw mix. Based on operating condition of the selected plant, four experimental campaigns of Cref (currently used raw mix, served as the reference), CH (modified from Cref, with a 15% increase in hematite but 15% decrease in limonite), CH,EP (modified from CH, without electrostatic precipitator (EP) and blast furnace (BF) flue dusts), and CH,EP,W (modified from CH,EP, with a 0.5 wt% increase in water content) were chosen. (more)

Ambient air pollution and risk of tuberculosis: A cohort study
Lai, TC;Chiang, CY;Wu, CF;Yang, SL;Liu, DP;Chan, CC;Lin, HH
Abstract: OBJECTIVES: Several respirable hazards, including smoking and indoor air pollution from biomass, were suggested to increase the risk of tuberculosis. Few studies have been conducted on ambient air pollution and tuberculosis. We investigated the association between exposure to ambient air pollution and incidence of active tuberculosis. (more)

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