2020 Publications

Urinary concentrations of phthalates in relation to circulating fatty acid profile in National Health and Nutrition Examination Survey, 2003–2004 and 2011–2012
Li, MC;Lin, CY;Guo, YL
The results of this comprehensive analyses suggest that phthalate metabolites may be correlated with circulating fatty acids. © 2020 Elsevier Ltd Animal studies have suggested that phthalate exposure alters the fatty acid composition of blood plasma. Therefore, we conducted an epidemiological study to examine whether urinary concentrations of phthalates are correlated with circulating fatty acids in the general US population.(more)

Urinary concentrations of phthalates in relation to circulating fatty acid profile in National Health and Nutrition Examination Survey, 2003–2004 and 2011–2012
Li, MC;Lin, CY;Guo, YL
The results of this comprehensive analyses suggest that phthalate metabolites may be correlated with circulating fatty acids. © 2020 Elsevier Ltd Animal studies have suggested that phthalate exposure alters the fatty acid composition of blood plasma. Therefore, we conducted an epidemiological study to examine whether urinary concentrations of phthalates are correlated with circulating fatty acids in the general US population.(more)

The sex-specific association of phthalate exposure with DNA methylation and characteristics of body fat in children
Chang, CH;Chen, CF;Tsai, YA;Wang, SL;Huang, PC;Chen, BH;Wu, MT;Chen, CC;Hsiung, CA;Chen, ML
The present study assessed the association between phthalate exposure and mitochondrial DNA (mtDNA) polymerase γ (POLG) methylation along with the potential effect on the characteristics of body fat in children. A total of 152 children were enrolled. The urinary concentrations of phthalate metabolites were measured using ultraperformance liquid chromatography-tandem mass spectrometry. (more)

Characterization of phthalate exposure in relation to serum thyroid and growth hormones, and estimated daily intake levels in children exposed to phthalate-tainted products: A longitudinal cohort study
Huang, PC;Chang, WH;Wu, MT;Chen, ML;Wang, IJ;Shih, SF;Hsiung, CA;Liao, KW
Background No information is available on the long-term effects on thyroid and growth hormones of children exposed to phthalate-tainted products, despite the infamous 2011 Taiwan phthalate episode. We investigated estimated daily intake levels and their long-term effects on serum thyroid and growth hormone levels in children.(more)

Continuous nationwide atmospheric PCDD/F monitoring network in Taiwan (2006-2016): Variation in concentrations and apportionment of emission sources
Ngo, TH;Yang, YH;Chen, YC;Pan, WC;Chi, KH
Atmospheric polychlorinated-dibenzo-dioxins/dibenzo-furans (PCDD/Fs) remains an important environmental health concern. Although the total emission inventories of PCDD/Fs in Taiwan decreased from 320 to 52.1 g-I-TEQ/year during 2002-2016, the resulting concentrations of atmospheric PCDD/F and distributions in Taiwan are unknown. (more)

Hyperactivity disorder in children related to traffic-based air pollution during pregnancy
Shih, P;Huang, CC;Pan, SC;Chiang, TL;Guo, YL
Background: Attention-deficit hyperactivity disorder (ADHD) is one of the most common neurobehavioral disorders in childhood globally. Between the two components of ADHD, hyperactivity disorder is more prevalent than inattention during early childhood. Although some investigations have implied a relationship between childhood ADHD and gestational exposure to air pollution, the evidence is limited.(more)

PM2.5 exposure of various microenvironments in a community: Characteristics and applications
Hsu, WT;Chen, JL;Candice Lung, SC;Chen, YC
While the measurement of particulate matter (PM) with a diameter of less than 2.5 μm (PM2.5) has been conducted for personal exposure assessment, it remains unclear how models that integrate microenvironmental levels with resolved activity and location information predict personal exposure to PM. We comprehensively investigated PM2.5 concentrations in various microenvironments and estimated personal exposure stratified by the microenvironment.(more)

Phthalate exposure causes browning-like effects on adipocytes in vitro and in vivo
Hsu, JW;Nien, CY;Yeh, SC;Tsai, FY;Chen, HW;Lee, TS;Chen, SL;Kao, YH;Tsou, TC
Mono(2-ethylhexyl)phthalate (MEHP) promotes adipogenesis via PPARγ. PPARγ agonists, e.g., rosiglitazone (RSG), enhance adipocyte browning. However, scientific evidence regarding MEHP as a browning chemical is lacking. This study combined 3T3-L1 adipocytes and C57BL/6J mice to examine the potential roles of MEHP in browning.(more)

Mediating role of oxidative/nitrosative stress biomarkers in the associations between phthalate exposure and thyroid function in Taiwanese adults
Huang, PC;Waits, A;Chen, HC;Chang, WT;Jaakkola, JJK;Huang, HB
Phthalate exposure was shown to alter thyroid function, however it is unclear, whether oxidative and nitrosative stress explains the intermediate biological mechanism. This study aimed to investigate the associations between phthalate exposure, oxidative/nitrosative stress, and thyroid function in adults, and to examine the mediating role of oxidative/nitrosative stress in the associations between phthalate exposure and thyroid function.(more)

Association between traffic count and cardiovascular mortality: A prospective cohort study in Taiwan
Pan, WC;Yeh, SY;Wu, CD;Huang, YT;Chen, YC;Chen, CJ;Yang, HI
BACKGROUND: Exposure to traffic-related pollution is positively associated with cardiovascular diseases (CVD), but little was known about how different sources of traffic pollution (e.g. gasoline-powered cars, diesel-engine vehicles) contribute to CVD. Therefore, we evaluated the association between exposure to different types of engine exhaust and CVD mortality.(more)

Curation of cancer hallmark-based genes and pathways for in silico characterization of chemical carcinogenesis
Liang, PI;Wang, CC;Cheng, HJ;Wang, SS;Lin, YC;Lin, P;Tung, CW
Exposure to toxic substances in the environment is one of the most important causes of cancer. However, the time-consuming process for the identification and characterization of carcinogens is not applicable to a huge amount of testing chemicals. The data gaps make the carcinogenic risk uncontrollable. An efficient and effective way of prioritizing chemicals of carcinogenic concern with interpretable mechanism information is highly desirable.(more)

New land use regression model to estimate atmospheric temperature and heat island intensity in Taiwan
Hsu, CY;Ng, UC;Chen, CY;Chen, YC;Chen, MJ;Chen, NT;Lung, SCC;Su, HJ;Wu, CD
This paper is about spatial–temporal variability of atmospheric temperature across Taiwan, an island with diverse local emission sources partly because of its Asian cultural characteristics. To develop a new land use regression (LUR) model for this study, we used the temperature data collected by the Taiwan Central Weather Bureau from 2000 and 2016, while using the data from 2017 as the external data verification to assess model reliability.(more)

Identification of ambient fine particulate matter components related to vascular dysfunction by analyzing spatiotemporal variations
Ho, CC;Chen, YC;Yet, SF;Weng, CY;Tsai, HT;Hsu, JF;Lin, P
Exposure to ambient fine particulate matter (PM2.5) has been associated with vascular diseases in epidemiological studies. We have demonstrated previously that exposure to ambient PM2.5 caused pulmonary vascular remodeling in mice and increased vascular smooth muscle cells (VSMCs) viability. (more)

The association between prenatal endocrine-disrupting chemical exposure and altered resting-state brain fMRI in teenagers
Weng, JC;Hong, CI;Tasi, JD;Shen, CY;Su, PH;Wang, SL
Many studies have reported that prenatal exposure to endocrine-disrupting chemicals (EDCs) can cause adverse behavioral effects or cognitive dysfunction in children. This study aimed to investigate a relationship of the concentration of prenatal EDCs and brain function in teenagers. We recruited 59 mother–child pairs during the third trimester of pregnancy, and collected and examined the concentration of EDCs, such as heavy metals, phthalates and perfluoroalkyl substances (PFASs), in maternal urine and serum.(more)

Prognostic significance of positive surgical margins for scalp angiosarcoma
Kuan, CH;Yang, HW;Huang, HF;Jyuhn-Hsiarn Lee, L;Tseng, TY;Hsieh, JH;Cheng, NC;Tai, HC;Lai, HS
Background: Scalp angiosarcomas (AS) are aggressive soft tissue sarcomas that present with outcomes different from other AS of the head and neck region. Due to the rarity of the disease, limited data on the clinical outcome of scalp AS are available. In particular, the prognostic significance of surgical margins remains controversial and the impact of margin status on survival has not been documented.(more)

Exposure to zinc oxide nanoparticles disrupts endothelial tight and adherens junctions and induces pulmonary inflammatory cell infiltration
Chen, CM;Wu, ML;Ho, YC;Gung, PY;Tsai, MH;Orekhov, AN;Sobenin, IA;Lin, P;Yet, SF
Zinc oxide nanoparticles (ZnONPs) are frequently encountered nanomaterials in our daily lives. Despite the benefits of ZnONPs in a variety of applications, many studies have shown potential health hazards of exposure to ZnONPs. We have shown that oropharyngeal aspiration of ZnONPs in mice increases lung inflammation.(more)

Association between microenvironment air quality and cardiovascular health outcomes
Tan, YQ;Rashid, SKA;Pan, WC;Chen, YC;Yu, LE;Seow, WJ
Exposure to fine particulate matter (PM2.5) is associated with cardiovascular disease risk. To date, there are few studies on short-term PM2.5 exposure in different microenvironments and its impact on immediate health effects, particularly in the Southeast Asia region. (more)

Characterization of striatal phenotypes in heterozygous Disc1 mutant mice, a model of haploinsufficiency
Baskaran, R;Lai, CC;Li, WY;Tuan, LH;Wang, CC;Lee, LJ;Liu, CM;Hwu, HG;Lee, LJ
Disrupted-in-Schizophrenia 1 (DISC1) is a susceptibility gene for several psychiatric illnesses. To study the pathogenesis of these disorders, we generated Disc1 mutant mice by introducing the 129S6/SvEv 25-bp deletion Disc1 variants into the C57BL/6J strain. In this study, we used heterozygous Disc1 mutant (Het) mice to evaluate the DISC1 haploinsufficiency model of schizophrenia.(more)

Simulating the spatiotemporal distribution of BTEX with an hourly grid-scale model
Hsieh, MT;Peng, CY;Chung, WY;Lai, CH;Huang, SK;Lee, CL
Modeling approaches have been utilized to simulate ambient pollutant concentrations, but very limited efforts have been made to estimate volatile organic compounds in the atmosphere. For this reason, an hourly grid-scale simulation model was developed to determine ambient air concentrations of benzene, toluene, ethylbenzene, and xylene (BTEX).(more)

Source and health risk apportionment for PM2.5 collected in Sha-Lu area, Taiwan
Tsai, PJ;Young, LH;Hwang, BF;Lin, MY;Chen, YC;Hsu, HT
Many investigations have found that the effects of chemical composition of PM2.5 plays an important role on human health. This study develops an air pollution source reduction strategy that apportions health risk among different emission sources by combining the receptor model and human health risk assessment technique. The goal is to identify emission source of PM2.5 that have the greatest impact on human health.(more)

Risk of hepatitis C virus infection in injecting and noninjecting drug users receiving opioid substitution therapy
Wang, CW;Chuang, HY;Chiang, HC;Huang, PC;Yu, ML;Dai, CY
BACKGROUND: Hepatitis C virus (HCV) is the most common viral infection among illicit drug users in the world. Although intervention of needle and syringe program and opioid substitution therapy had engaged to prevent HCV infection, the prevalence of HCV infection does not seem to decline. The aim of this study was to estimate the risk of HCV infection in injecting drug users (IDUs) and noninjecting drug users (NIDUs) receiving opioid substitution therapy. (more)

MEHP interferes with mitochondrial functions and homeostasis in skeletal muscle cells
Chen, YH;Wu, YJ;Chen, WC;Lee, TS;Tsou, TC;Chang, HC;Lo, SW;Chen, SL
Di (2-ethylhexyl) phthalate (DEHP) is a plasticizer frequently leached out from polyvinyl chloride (PVC) products and is quickly metabolized to its monoester equivalent mono(2-ethylhexyl) phthalate (MEHP) once enters organisms. (more)

Periconceptional exposure to air pollution and congenital hypospadias among full-term infants
Huang, CC;Pan, SC;Chen, BY;Guo, YL
BACKGROUND: Evidence regarding whether prenatal exposure to air pollution increases the risk of hypospadias remains limited. The aim of the study is to evaluate the association between exposure to ambient air pollution during early pregnancy and the incidence of hypospadias. (more)

The roles of lumbar load thresholds in cumulative lifting exposure to predict disk protrusion in an Asian population
Hung, IY;Shih, TT;Chen, BB;Liou, SH;Ho, IK;Guo, YL
BACKGROUND: The purpose of this study was to determine whether a specific threshold per lifting movement, the accumulation above which best predicts lumbar disk protrusion, exists or the total lifting load should be considered. (more)

Phthalate exposure increased the risk of early renal impairment in Taiwanese without type 2 diabetes mellitus
Chang, JW;Liao, KW;Huang, CY;Huang, HB;Chang, WT;Jaakkola, JJK;Hsu, CC;Chen, PC;Huang, PC
Studies have suggested that phthalates may be a risk factor for microalbuminuria, whereas little is known regarding their nephrotoxic effects on adults. We enrolled 311 participants (>/=18 y, N = 241; <18 y, N = 70) who provided questionnaire information as well as blood and urine samples from a nationally cross-sectional study.(more)

Phthalate exposure and prostate cancer in a population-based nested case-control study
Chuang, SC;Chen, HC;Sun, CW;Chen, YA;Wang, YH;Chiang, CJ;Chen, CC;Wang, SL;Chen, CJ;Hsiung, CA
BACKGROUND: Phthalic acid esters are established as endocrine disruptors. The study aimed to evaluate the association between urinary phthalate metabolites and prostate cancer occurrence.(more)

Association between air pollution exposure and diabetic retinopathy among diabetics
Pan, SC;Huang, CC;Chin, WS;Chen, BY;Chan, CC;Guo, YL
BACKGROUND: Exposure to air pollution has been linked to adverse effects on vascular diseases. However, the effects of air pollution exposure on diabetic retinopathy (DR), a vascular disease, have not been studied. OBJECTIVE: To determine the association of ambient air pollution exposure with DR risk.(more)

Leveraging complementary computational models for prioritizing chemicals of developmental and reproductive toxicity concern: An example of food contact materials
Tung, CW;Cheng, HJ;Wang, CC;Wang, SS;Lin, PP
The evaluation of developmental and reproductive toxicity of food contact materials (FCMs) is an important task for food safety. Since traditional experiments are both time-consuming and labor-intensive, only a small number of FCMs have sufficient toxicological data for evaluating their effects on human health.(more)

Prenatal and childhood phthalate exposure and attention deficit hyperactivity disorder traits in child temperament: A 12-year follow-up birth cohort study
Ku, HY;Tsai, TL;Wang, PL;Su, PH;Sun, CW;Wang, CJ;Wang, SL
Temperamental tendencies may form the basis of personality development, and specific personality constellations are associated with increased incidences of behavioural problems. Phthalic acid ester (PAE) has been associated with symptoms of attention deficit hyperactivity disorder (ADHD) in cross-sectional studies. We hypothesised that early-life exposure to PAE affects the temperaments of children, particularly ADHD traits.(more)

PCAF-mediated acetylation of ISX recruits BRD4 to promote epithelial-mesenchymal transition
Wang, LT;Liu, KY;Jeng, WY;Chiang, CM;Chai, CY;Chiou, SS;Huang, MS;Yokoyama, KK;Wang, SN;Huang, SK;Hsu, SH
Epigenetic regulation is important for cancer progression; however, the underlying mechanisms, particularly those involving protein acetylation, remain to be fully understood. Here, we show that p300/CBP-associated factor (PCAF)-dependent acetylation of the transcription factor intestine-specific homeobox (ISX) regulates epithelial-mesenchymal transition (EMT) and promotes cancer metastasis.(more)

Association between urine lead levels and cardiovascular disease risk factors, carotid intima-media thickness and metabolic syndrome in adolescents and young adults
Lin, CY;Huang, PC;Wu, C;Sung, FC;Su, TC
BACKGROUND: Environmental lead exposure is a known risk factor of cardiovascular disease (CVD) in animal and human epidemiological studies of adults, but limited research has been conducted in young populations. Moreover, the association between lead level and common carotid artery intima-media thickness (CIMT) has never been documented.(more)

PM2.5 disturbs the balance of Th17/Treg cells by targeting Got1 and HIF-1alpha in an asthma model
Sun, L;Fu, J;Lin, SH;Sun, JL;Xia, L;Lin, CH;Liu, L;Zhang, C;Yang, L;Xue, P;Wang, X;Huang, S;Han, X;Chen, HL;Huang, MS;Zhang, X;Huang, SK;Zhou, Y
BACKGROUND: Epidemiologic evidence suggests that exposure to PM2.5 aggravates asthma. OBJECTIVE: Investigate the underlying mechanisms between PM2.5 exposure and asthma severity. METHODS: The relationship between PM2.5 exposure and asthma severity was investigated in an asthma model with CD4(+) T cell-specific aryl hydrocarbon receptor (AhR) null mice.(more)

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